Jason G. Kettle: шукати на сайті Z-Library

Рік:

2020

Мова:

english

Файл:

PDF, 1.12 MB

english, 2020

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

Catherine Bardelle, Darren Cross, Sara Davenport, Jason G. Kettle, Eun Jung Ko, Andrew G. Leach, Andrew Mortlock, Jon Read, Nicola J. Roberts, Peter Robins, Emma J. Williams

Журнал:

Expert Opinion on Therapeutic Patents

Рік:

2008

Мова:

english

Файл:

PDF, 356 KB

english, 2008

Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, Part 2

Kettle, Jason G., Åstrand, Annika, Catley, Matthew, Grimster, Neil P., Nilsson, Magnus, Su, Qibin, Woessner, Richard

Журнал:

Рік:

2016

Мова:

english

Файл:

PDF, 780 KB

english, 2016

Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, Part 1

Kettle, Jason G., Åstrand, Annika, Catley, Matthew, Grimster, Neil P., Nilsson, Magnus, Su, Qibin, Woessner, Richard

Журнал:

Expert Opinion on Therapeutic Patents

Рік:

2016

Мова:

english

Файл:

PDF, 777 KB

english, 2016

Covalent inhibitors of the GTPase KRAS G12C : a review of the patent literature

Kettle, Jason G., Cassar, Doyle J.

Журнал:

Expert Opinion on Therapeutic Patents

Рік:

2020

Файл:

PDF, 2.17 MB

2020

Alkene–Arene meta Photocycloadditions with a Four-Carbon-Atom Tether: Efficient Approach toward the Polycyclic Ring Systems of Aphidicolin and Stemodinone

Joseph W. Boyd, Nicola Greaves, Jason Kettle, Andrew T. Russell, Jonathan W. Steed

Журнал:

Angewandte Chemie

Рік:

2005

Мова:

english

Файл:

PDF, 115 KB

english, 2005

Alkene–Arene meta Photocycloadditions with a Four-Carbon-Atom Tether: Efficient Approach toward the Polycyclic Ring Systems of Aphidicolin and Stemodinone

Joseph W. Boyd, Nicola Greaves, Jason Kettle, Andrew T. Russell, Jonathan W. Steed

Журнал:

Angewandte Chemie International Edition

Рік:

2005

Мова:

english

Файл:

PDF, 115 KB

english, 2005

ChemInform Abstract: Synthesis of Subunits of Marine Polycyclic Ethers by Ring-Closing Metathesis and Hydroboration of Enol Ethers.

J. Stephen Clark, Jason G. Kettle

Журнал:

Jason G. Kettle, Alan W. Faull, Shaun M. Fillery, Anthony P. Flynn, Marcus A. Hoyle, Julian A. Hudson

Рік:

1999

Файл:

PDF, 31 KB

1999

ChemInform Abstract: Facile Synthesis of 3-Alkoxyindoles via Rhodium(II)-Catalyzed Diazoindole O—H Insertion Reactions.

Журнал:

Рік:

2000

Файл:

PDF, 30 KB

2000

N-Benzylindole-2-carboxylic Acids: Potent Functional Antagonists of the CCR2b Chemokine Receptor.

Jason G. Kettle, Alan W. Faull, Andy J. Barker, D. Huw Davies, Michael A. Stone

Журнал:

Craig S. Harris, Jason G. Kettle, Emma J. Williams

Рік:

2004

Файл:

PDF, 81 KB

2004

Facile Synthesis of 7-Amino Anilinoquinazolines via Direct Amination of the Quinazoline Core.

Журнал:

Jason G. Kettle, David Roberts, John A. Joule

Рік:

2006

Файл:

PDF, 24 KB

2006

ChemInform Abstract: Synthesis of 1,2,3,4,5,7-Hexahydro-6H-azocino[4,3-b]indol-6-ones as Intermediates for the Synthesis of Apparicine.

Журнал:

Рік:

2011

Файл:

PDF, 38 KB

2011

Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics

Peter Ballard, Robert H. Bradbury, Craig S. Harris, Laurent F.A. Hennequin, Mark Hickinson, Jason G. Kettle, Jane Kendrew, Teresa Klinowska, Donald J. Ogilvie, Stuart E. Pearson, Emma J. Williams, Ing

Журнал:

Рік:

2006

Мова:

english

Файл:

PDF, 136 KB

english, 2006

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, Peter Ballard, Robert H. Bradbury, Richard Ducray, Hervé Germain, D. Mark Hickinson, Kevin Hudson, Jason G. Kettle, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivi

Журнал:

Рік:

2008

Мова:

english

Файл:

PDF, 134 KB

english, 2008

N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor

Jason G. Kettle, Alan W. Faull, Andy J. Barker, D.Huw Davies, Michael A. Stone

Журнал:

Рік:

2004

Мова:

english

Файл:

PDF, 160 KB

english, 2004

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

Andrew Baxter, Steve Brough, Anne Cooper, Eike Floettmann, Steve Foster, Christine Harding, Jason Kettle, Tom McInally, Craig Martin, Michelle Mobbs, Maurice Needham, Pete Newham, Stuart Paine, Steve

Журнал:

Рік:

2004

Мова:

english

Файл:

PDF, 385 KB

english, 2004

5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase

Peter Ballard, Robert H. Bradbury, Laurent F.A. Hennequin, D. Mark Hickinson, Paul D. Johnson, Jason G. Kettle, Teresa Klinowska, Remy Morgentin, Donald J. Ogilvie, Annie Olivier

Журнал:

Рік:

2005

Мова:

english

Файл:

PDF, 219 KB

english, 2005

Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket

Peter Ballard, Robert H. Bradbury, Craig S. Harris, Laurent F.A. Hennequin, Mark Hickinson, Paul D. Johnson, Jason G. Kettle, Teresa Klinowska, Andrew G. Leach, Remy Morgentin, Martin Pass, Donald J.

Журнал:

Peter Ballard, Bernard C. Barlaam, Robert H. Bradbury, Allan Dishington, Laurent F.A. Hennequin, D. Mark Hickinson, Ian M. Hollingsworth, Jason G. Kettle, Teresa Klinowska, Donald J. Ogilvie, Stuart E

Рік:

2006

Мова:

english

Файл:

PDF, 245 KB

english, 2006

Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Журнал:

Richard Ducray, Peter Ballard, Bernard C. Barlaam, Mark D. Hickinson, Jason G. Kettle, Donald J. Ogilvie, Catherine B. Trigwell

Рік:

2007

Мова:

english

Файл:

PDF, 143 KB

english, 2007

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Журнал:

Рік:

2008

Мова:

english

Файл:

PDF, 129 KB

english, 2008

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines

Catherine Bardelle, Tanya Coleman, Darren Cross, Sara Davenport, Jason G. Kettle, Eun Jung Ko, Andrew G. Leach, Andrew Mortlock, Jon Read, Nicola J. Roberts, Peter Robins, Emma J. Williams

Журнал:

Рік:

2008

Мова:

english

Файл:

PDF, 348 KB

english, 2008

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Bernard Barlaam, Richard Ducray, Christine Lambert-van der Brempt, Patrick Plé, Catherine Bardelle, Nigel Brooks, Tanya Coleman, Darren Cross, Jason G. Kettle, Jon Read

Журнал:

Emma J. Williams, Peter W. Kenny, Jason G. Kettle, Paul G. Mwashimba

Рік:

2011

Мова:

english

Файл:

PDF, 353 KB

english, 2011

Synthesis of a 5-alkoxypyrido[4,3-d]pyrimidin-4(3H)-one derivative via a regioselective Meisenheimer N-oxide rearrangement

Журнал:

Allan P. Dishington, Paul D. Johnson, Jason G. Kettle

Рік:

2004

Мова:

english

Файл:

PDF, 270 KB

english, 2004

Synthesis of a 5-alkoxypyrido[3,4-d]pyrimidin-4(3H)-one derivative via directed ortho-metallation of a pyridine analogue

Журнал:

Craig S. Harris, Jason G. Kettle, Emma J. Williams

Рік:

2004

Мова:

english

Файл:

PDF, 243 KB

english, 2004

Facile synthesis of 7-amino anilinoquinazolines via direct amination of the quinazoline core

Журнал:

Craig S. Harris, Laurent F. Hennequin, Jason G. Kettle, Olivier A. Willerval

Рік:

2005

Мова:

english

Файл:

PDF, 108 KB

english, 2005

Selective alkylation of a 6,7-dihydroxyquinazoline

Журнал:

J. Stephen Clark, Jason G. Kettle

Рік:

2005

Мова:

english

Файл:

PDF, 115 KB

english, 2005

Enantioselective synthesis of medium-ring sub-units of brevetoxin A by ring-closing metathesis

Журнал:

J Stephen^Clark, Jason G Kettle

Рік:

1997

Мова:

english

Файл:

PDF, 224 KB

english, 1997

Synthesis of brevetoxin sub-units by sequential ring-closing metathesis and hydroboration

Журнал:

J. Stephen Clark, Jason G. Kettle

Рік:

1997

Мова:

english

Файл:

PDF, 237 KB

english, 1997

Synthesis of sub-units of marine polycyclic ethers by ring-closing metathesis and hydroboration of enol ethers

Журнал:

Tetrahedron

Рік:

1999

Мова:

english

Файл:

PDF, 1.43 MB

english, 1999

Facile synthesis of 3-alkoxyindoles via rhodium(II)-catalysed diazoindole O–H insertion reactions

Jason G Kettle, Alan W Faull, Shaun M Fillery, Anthony P Flynn, Marcus A Hoyle, Julian A Hudson

Журнал:

Ward, Richard A., Kettle, Jason G.

Рік:

2000

Мова:

english

Файл:

PDF, 112 KB

english, 2000

Systematic Enumeration of Heteroaromatic Ring Systems as Reagents for Use in Medicinal Chemistry

Журнал:

Journal of Pharmacological and Toxicological Methods

Рік:

2011

Мова:

english

Файл:

PDF, 1.01 MB

english, 2011

In vitro pharmacological profiles of kinase inhibitors: Comparison with other pharmaceuticals

Richard W.A. Luke, Mike G. Rolf, Rob H. Bradbury, Ed J. Griffen, Neil J. Hales, Jason Kettle, Andrew P. Thomas, Joanne Bowes, Jean-Pierre Valentin, Andy J. Barker

Журнал:

Рік:

2009

Мова:

english

Файл:

PDF, 53 KB

english, 2009

Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT

Kettle, Jason G., Brown, Simon, Crafter, Claire, Davies, Barry R., Dudley, Phillippa, Fairley, Gary, Faulder, Paul, Fillery, Shaun, Greenwood, Hannah, Hawkins, Janet

Журнал:

Kettle, Jason G., Ward, Richard A., Griffen, Ed

Рік:

2012

Мова:

english

Файл:

PDF, 1.70 MB

english, 2012

Data-mining patent literature for novel chemical reagents for use in medicinal chemistry design

Журнал:

MedChemComm

Рік:

2010

Мова:

english

Файл:

PDF, 176 KB

english, 2010

Toward the Comprehensive Systematic Enumeration and Synthesis of Novel Kinase Inhibitors Based on a 4-Anilinoquinazoline Binding Mode

Kettle, Jason G., Ward, Richard A.

Журнал:

Journal of Chemical Information and Modeling

Рік:

2010

Мова:

english

Файл:

PDF, 301 KB

english, 2010

Discovery of 4-Amino- N -[(1 S )-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Addie, Matt, Ballard, Peter, Buttar, David, Crafter, Claire, Currie, Gordon, Davies, Barry R., Debreczeni, Judit, Dry, Hannah, Dudley, Philippa, Greenwood, Ryan, Johnson, Paul D., Kettle, Jason G., La

Журнал:

Barker, Andy, Kettle, Jason G., Nowak, Thorsten, Pease, J. Elizabeth

Рік:

2013

Мова:

english

Файл:

PDF, 920 KB

english, 2013

Expanding medicinal chemistry space

Журнал:

Drug Discovery Today

Рік:

2013

Мова:

english

Файл:

PDF, 304 KB

english, 2013

Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors

Barlaam, Bernard, Anderton, Judith, Ballard, Peter, Bradbury, Robert H., Hennequin, Laurent F. A., Hickinson, D. Mark, Kettle, Jason G., Kirk, George, Klinowska, Teresa, Lambert-van der Brempt, Christ

Журнал:

ACS Medicinal Chemistry Letters

Рік:

2013

Мова:

english

Файл:

PDF, 2.13 MB

english, 2013

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

Burton, Rebecca J., Crowther, Mandy L., Fazakerley, Neal J., Fillery, Shaun M., Hayter, Barry M., Kettle, Jason G., McMillan, Caroline A., Perkins, Paula, Robins, Peter, Smith, Peter M., Williams, Emm

Журнал:

Goldberg, Frederick W., Kettle, Jason G., Xiong, Jian, Lin, Daoguang

Рік:

2013

Мова:

english

Файл:

PDF, 293 KB

english, 2013

General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor

Журнал:

Tetrahedron

Рік:

2014

Мова:

english

Файл:

PDF, 526 KB

english, 2014

Designing novel building blocks is an overlooked strategy to improve compound quality

Goldberg, Frederick W., Kettle, Jason G., Kogej, Thierry, Perry, Matthew W.D., Tomkinson, Nick P.

Журнал:

Drug Discovery Today

Рік:

2015

Мова:

english

Файл:

PDF, 1012 KB

english, 2015

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr 286 , not Thr 288

Ashford, Anne L., Oxley, David, Kettle, Jason, Hudson, Kevin, Guichard, Sylvie, Cook, Simon J., Lochhead, Pamela A.

Журнал:

Biochemical Journal

Рік:

2014

Мова:

english

Файл:

PDF, 1.12 MB

english, 2014

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Winter, Jon J. G., Anderson, Malcolm, Blades, Kevin, Brassington, Claire, Breeze, Alexander L., Chresta, Christine, Embrey, Kevin, Fairley, Gary, Faulder, Paul, Finlay, M. Raymond V., Kettle, Jason G.

Журнал:

Рік:

2015

Мова:

english

Файл:

PDF, 9.61 MB

english, 2015

Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis

Kettle, Jason G., Ballard, Peter, Bardelle, Catherine, Cockerill, Mark, Colclough, Nicola, Critchlow, Susan E., Debreczeni, Judit, Fairley, Gary, Fillery, Shaun, Graham, Mark A., Goodwin, Louise, Guic

Журнал:

Kettle, Andrew J., Carere, Jason, Batley, Jacqueline, Benfield, Aurelie H., Manners, John M., Kazan, Kemal, Gardiner, Donald M.

Рік:

2015

Мова:

english

Файл:

PDF, 2.67 MB

english, 2015

A γ-lactamase from cereal infecting Fusarium spp. catalyses the first step in the degradation of the benzoxazolinone class of phytoalexins

Журнал:

Fungal Genetics and Biology

Рік:

2015

Мова:

english

Файл:

PDF, 1.62 MB

english, 2015

The Fdb3 transcription factor of the Fusarium Detoxification of Benzoxazolinone gene cluster is required for MBOA but not BOA degradation in Fusarium pseudograminearum

Kettle, Andrew J., Carere, Jason, Batley, Jacqueline, Manners, John M., Kazan, Kemal, Gardiner, Donald M.

Журнал:

Fungal Genetics and Biology

Рік:

2016

Мова:

english

Файл:

PDF, 1.65 MB

english, 2016

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Kettle, Jason G., Alwan, Husam, Bista, Michal, Breed, Jason, Davies, Nichola L., Eckersley, Kay, Fillery, Shaun, Foote, Kevin M., Goodwin, Louise, Jones, David R., Käck, Helena, Lau, Alan, Nissink, J.

Журнал: